All about nootropics (smart drugs) and what they are.

Here’s the basics of what nootropics are.  Nootropics are smart drugs.  Nootropics have different sub-categories and different effects. Imagine having more confidence, energy, problem solving skills, and being able to study for hours without getting too tired and only needing small breaks. If you’ve seen the movie Limitless, you’re somewhat familiar with the idea of drugs that improve memory, confidence, and problem solving skills. Nootropics aren’t, however, a substitute for a healthy life, clean digestion, adequete sleep(8 hours), or mild to moderate excersise. Nootropic work best as a supplement to yearly colon cleansing and a healthy lifestyle. That said, nootropics can boost your cognition. Some nootropics enhance problem solving skills and memory. Some nootropics have anxiolytic (anti anxiety) properties.  Some nootropics enhance focus and concentration.  Some nootropics have stimulant effects and can give you energy and may increase confidence. Some nootropics are psychedelics, but are non toxic and are nootropics at low doses. 2C-x series is a prominent example. The 2C-x at low doses permanently boosts cognition and works better if you’re already smart. Nootropics must not be confused with cognitive enhancers.

Pre-disclaimer: Check your local laws for legality of each compound(though most of them are technically legal).

Disclaimer:This article is for informational purposes only and should not constitute medical, professional, or legal advice. It’s also worth noting that governments are actively trying to make nootropics and euchemics(better living though chemistry) illegal one by one. Though more nootropics and euchemics are synthesized way faster than they could illegalize, that’s one good thing. However people like Rob Portman and others pass draconian legislation based on setting back science and advancing their political and wealth and knowledge hogging adenda. Check your local laws for legality of each compound(though most of them are technically legal). The ones in control fuel hatred, people going mad with power, racism, and countless crimes and never create drug laws or nootropics and euchemic laws based on science and actual risk of harm, but on maintaining power. They stop responsible occasional fun, responsible psychical and cognitive enhancement, and repress higher truths.

Mild to semi-moderate activation seems to have cognitive enhancing properties. Therefore, it’s not that surprising to see 2C-x at low doses to have nootropic properties or for IAP(IndanylAminoPropane) to have nootropic properties since IAP only weakly affects the 5HT2a receptors in the brain.  Activation beyond the semi-moderate stage, as in moderate to severe has, however been associated with mild to severe hallucinations.

Some nootropics are becoming illegal due to it’s popularity rivaling the popularity of alcohol (ethyl alcohol) and due to a decline in people’s consumption of the more low brow moronic media constantly doled out by government influences. As such, a disclaimer becomes necessary.

This blog and other related blogs are for educational purposes only and should not constitute medical, professional, or legal advice.

Here’s a classification of cognitive enhancers.

Hypranootropics(super nootropics)
Nootropics(permanent cognitive enhancement)
Quasinootropics(temporary cognitive increase, little or no brain damage)
Pseudonootropics(fake nootropics. The effect is temporary and there’s extensive damage, toxicity, and a host of side effects including high addiction potential, blackouts and brain damage)

Side note: Nootropics include mild nootropic, moderate nootropics, and nootropics.

Here are the nootropic sub-categories. They are:

Anxiolytic (anti anxiety)

Stimulants

Wakefulness enhancers(eugeroics)

Mood lifters

Concentration enhancers

Memory and problem solving skills enhancers.

Supplements.

Anti-oxidants.

Neuron growers (neurogenesis inducers).

Other (ambiguous, undefined nootropic properties).

This is your brain. This is your brain on nootropics. Chicken egg vs ostrich egg.

A breakdown of nootropics.

Anxiolytic (anti anxiety).

Anxiolytic drugs are drugs that reduce anxiety. They reduce extreme anxiety, and relieve anxiety in general. A little anxiety does not interfere with cognition. It may even help. However, excessive anxiety can be debilitating and anti anxiety drugs are usually needed.

Here’s a list of anti-anxiety agents. They are:

Benzodiazepines. – Benzodiazepines like vallium and klonopin can be used short term for the treatment of extreme anxiety. However, long term use is not advised as benzodiazepines are Quasinootropics. They only work short-term. As such, long term use (more than 7 months) or irresponsible misuse may cause serious side effects.

GHB. Gamma-hydroxy butyric acid. – GHB is known to reduce anxiety, protect the muscles, and increase human growth hormone. As such, it was used as a body building supplement and an anxiolytic. It’s classified in the quasinootropic class of cognitive enhancers (although some may suggest that pseudonootropic is a more suitable classification). Dose range is 0.5mL to 3.5mL.  Use once a week or less often.

2m2bOH. 2-methyl-2-butyl alcohol or 2-methyl-2-butanol. –  2-methyl-2-butanol is a lab solvent that is sometimes used as an anti-anxiety drug. It’s metabolised via gluconorization and p 450 oxidation. It’s metabolism produces 2-methyl-2-butyl gluconoride and 2-methyl-2,3-butanediol. These are non-toxic metabolites. The metabolism of booze(ethanol) produces acetabdehyde(a toxic metabolite). It does some damage before metabolising into acetic acid(a non toxic metabolite). Ethanol is metabolised via alcohol dehydrogenase. 2m2bOH(2-methyl-2-butanol) produces anti-anxiety effects and also increases sociability. It’s also a mood lifter. The dose range is 2ml to 6ml dissolved in 8 oz of juice or fruit punch and with 2ml to 10ml of ethanol(to increase solubility). It’s used no more than a few times a week. It’s classified as a quasinootropic.

PWZ-029.- PWZ-029 is a benzodiazepine derived drug with anti-anxiety and nootropic properties. It can be used either alone or stacked with other anti-anxiety drugs and/or nootropics. PWZ is classified as a nootropic. It would be especially awesome to stack with benzodiazepines to conteract the negative side effects of benzodiazepines somewhat and to conteract the possible memory dampening effects of benzodiazepines.

2C-C (2,5-Dimethoxy-4–Chlorophenethylamine) – 2C- C is a psychedelic drug of the 2C-x family that is an anti anxiety at low doses. At 20mg to 40mg, it affects 5HT2a in a moderate to severe way and can cause hallucinations. However, at lower doses(5mg to 15mg), 2C-C affects 5HT2a only mildly to semi-moderately. As such, it exibits anxiolytic effects. 2C-C also affects serotonin and, to a lesser extent, dopamine and norephinephrine.

Baclofen – Baclofen is an anti anxiety drug that regulates body temperature. As such, it helps prevent overheating caused by ecstasy (MDxx series: MDA, MDMA, MDEA, ect.) . If you’re planning to take ecstasy, it would be a good idea to stack it with 10mg to 20mg of baclofen. That way, you’re less likely to overheat. Overheating is the number one cause of ecstasy related death. The dose range of baclofen is 10mg to 20mg. Baclofen is classified as a nootropic.

MCOPPB – MCOPPB is a novel anti anxiety drug that produces potent anti-anxiety effects without producing any memory inpairments or short term memory loss. This compound also may have painkilling effects. It has only been tested in animals, though the starting dose is estimated to be about 10mg to 50mg. Just 10mg can cost over $150 dollars. Shocking! It’s usually only used for research porpuses.

Stimulants

Stimulants are a class of drugs that stimulate the mind and body and increases energy levels.  They increase productivity and locomotion. They cause a temporary increase in energy levels, sometimes followed by a crash. They give you a rush of energy that makes you want to do stuff. They are sometimes called productivity enhancers. Stimulants can sometimes cause dependence and side effects. They do not prevent the side effects of sleep deprivation, so staying up for long periods of time will still cause sleep deprived induced hallucinations, and sleep deprived induced psychosis.

Here’s a list of stimulants nootropics:

DMAA (1,3-dimethylamylamine)- Dimethylamylamine is a stimulant drug that is similar to amphetamine, but has nearly none of the high or negative side effects. It’s a drug that can be used as a pre-workout supplement and as a study-aid.  The dose range is 25mg to 50mg. It can be used daily. It’s classified as a quasinootropic. DMAA has little known side effects and is unlikely to cause death at normal dosages. This drug is thermogenic(meaning it causes the body to heat up more), but this is due to a heightened metabolism. DMAA is usually used as a pre-workout, since it’s very low release of dopamine makes it a poor study aid. Though the very low dopamine release is also a reason that DMAA is relatively non-addictive. DMAA tends to enhance physical strength and physical energy and you’ll want to work out like crazy. If you find the extra heat annoying, DMAA can be stacked with 10mg to 20mg of Baclofen to prevent the increased heat.

Thiopropamine- Thiopropamine is used as a stimulant. It’s described as weaker than DMAA. Not much is known about Thiopropamine, mainly due to it’s limited human use or availability. Nonetheless, it would still be interesting to explore. It’s listed as a quasinootropic.

EthylAmphetamine (N-EthylAmphetamine)- Ethylamphetamine is a stimulant drug similar to amphetamine. The dose range is 5mg to 15mg. This one should be avoided as it’s a pseudonootropic. Long term cognitive damage can occur.

PropylAmphetamine (N-PropylAmphetamine)- Propylamphetamine is a stimulant similar to amphetamine, but with 1/4 of the potency. The dose range is 5mg to 30mg. This one is a quasinootropic.

Tametraline – Tametraline is a dopamine norepinephrine reuptake inhibitor with stimulant properties. It has been compared to adderall and ritalin, though tametraline is less likely to cause addiction than adderall or ritalin. The dose range of tametraline is 25mg to 50mg. It’s a quasinootropic.

IsopropylAmphetamine (N-IsopropylAmphetamine) – IsopropylAmphetamine is a stimulant that is weaker than amphetamine, but longer lasting.

Indanetraline- Indanetraline is a novel stimulant. The dose range is 20mg to 50mg.

Prolintane – Prolintane is stronger than caffeine, yet smooter and less habit forming. Prolintane is non addictive and enhances concentration, energy and motivation to a much greater degree than caffeine. Prolintane has a very good safety profile. Prolintane’s dose range is 20mg to 40mg in a day. Prolintane lasts 7 hours to over 12 hours. Prolintane is sometimes referred to as “Vitamin P”. Prolintane is generally used 2 to 5 times a week. Prolintane is a safe stimulant nootropic.

AceticBenzylPiperazine – AceticBenzylPiperazine lifts mood and increases energy. It also improves cognition. The dose range is 5mg to 40mg. It’s classified as a nootropic.

Zylofuramine – Zylofuramine is a stimulant that was never marketed or tested.

Z-17:  Z-17 is an experimental stimulant that is stronger than methylphenidate. The dose range is 5mg to 30mg. This is classified as a quasinootropic (possibly a pseudonootropic).

Arecoline – Arecoline is a stimulant drug found in the areca nut. It’s a nootropic.

2C-I (2,5-Dimethoxy-4-IodoPhenethylamine) – 2C-I is a psychedelic drug that acts as a stimulant at low doses. It also elevated mood at low doses. The nootropic dose range of 2C-I is 1mg to 12mg. 2C-I is classified as a hypranootropic.

1-Cyclopentyl-2-AminoPropane:  1-Cyclopentyl-2-AminoPropane, CyclopentylAminoPropane, Cyclopentylaminopropane, or CAP, is a stimulant related to cyclopentamine and amphetamine. It’s much weaker than amphetamine and cyclopentamine, though it’s said to be more mentally stimulating than DMAA(dimethylamylamine). DMAA stimulantes mostly adrenaline and norepinephrine, with very little stimulation of dopamine. While 1-cyclopentyl-2-aminopropane and cyclopentamine are said to stimulate adrenaline, norepinephrine, and dopamine, leading it to be a better study aid. 

1-Cyclohexyl-2-aminopropane, CycloHexylAminoPropane, Cyclohexylaminopropane, or “CHAP” is a stimulant related to Propylhexedrine. Cyclohexylaminopropane is said to be a much more effective stimulant than cyclopentylaminopropane, due to activation of TAAR1 receptors and VMAT2 receptors, and a much larger release of mainly norepinephrine and dopamine. Propylhexedrine is said to be 1/4 of the potency of amphetamine, being an effective yet relatively safe stimulant. The dose range of Cyclohexylaminopropane is 20mg to 150mg.

Caffeine – Caffeine is a primative stimulant that disrupts adenosine receptors, jitteryness, cortisol levels, and is mainly a fatigue perception reducer. Caffeine mimics the effects of stimulants. Caffeine has a moderate dependence liability, and does not really increase cognition. Caffeine is often used for waking up in the morning, when eugeroics are much more suitable for this purpose. Caffeine can become addictive.

Wakefulness enhancers(eugeroics)

Wakefulness enhancers, or eugeroics, are drugs that can keep you feeling awake and refreshed and even more alert without the negative side effects of stimulants. Wakefulness enhancers have only a low to low-moderate dependence potential, and are not addictive. While wakefulness enhancers may not cause much of an increase in energy levels, wakefulness enhancers increase wakefulness and sometimes focus. Eugeroics allow you to productively use your pre-existing intelligence. Shorter lasting wakefulness enhancers will wake you up in the morning better than coffee and it’s also suitable for if you get sleepy in the afternoon, or have excessive daytime sleepiness. Longer lasting eugeroics(wakefulness enhancers) will allow you to stay up half the night, or for extended periods of time without going through the side effects of sleep deprivation. Wakefulness enhancers may be subtle, but they’re the most effective compounds for being fully awake whether you got a full night sleep or not. Avoiding food and airborne allergens and food intolerance that you have are advised, as wakefulness enhancers tend to increase the histaminergic response.

Fluorenol – Fluorenol(also called hydrafinil) is an eugeroic(wakefulness enhancer) that is less addictive than modafinil while being 40% more effective than modafinil. The dose range of fluorenol is 50mg to 200mg. Fluorenol also causes less dopamine release than modafinil. This compound is classified as a nootropic. The duration is 3 to 6 hours. Hydrafinil(fluorenol) is best suited in the morning and the afternoon. Fluorenol is also a 5HT6 antagonists, so it can increase dopamine and norepinephrine in the hippocampus, leading to a subtle yet noticeable boost in mood and cognition. The combined benefits of 5HT6 antagonism, short duration, and powerful eugeroic effects are what makes fluorenol an ideal eugeroic for those who still want to sleep at night and not wait super long for the eugeroic to wear off.

Flodafinil – Flodafinil(also called CRL-40,940; Flmodafinil; Fluoromodafinil) is an eugeroic(wakefulness enhancer) that is a modified form of modafinil. The fluorine substitution increases the potency to around 2 to 4 times that of modafinil. The dose range is 25mg to 200mg and the duration is 9+ hours. Side effects may include: nausea, upset stomach, and mild headaches. Staying hydrated and fed is advised, and taking choline can sometimes help too. Flmodafinil is very effective for staying up at night. It’s suitable for if you have to stay up at night, and for staying up after not getting enough sleep. Flodafinil(CRL-40,940) must not be confused with Fladrafinil(CRL-40,941).

Modafinil – Modafinil was one of the first wakefulness enhancers discovered. Modafinil is a pretty weak wakefulness enhancer, but was leagues ahead of caffeine. Modafinil lasts around 7 to 8 hours. The newer eugeroics(wakefulness enhancers) created beyond modafinil are stronger and has fewer side effects than modafinil. The side effects of the newer eugeroics are also generally milder than modafinil. Side effects may include: nausea, upset stomach, and mild headaches. Staying hydrated and fed is advised, and taking choline can sometimes help too. The dose range of modafinil is 50mg to 400mg. It’s also worth noting that modafinil is a scheduled drug in some countries, and unlike the newer eugeroics, modafinil is usually only available by prescription.

Mood lifters.

Mood lifters are drugs that safely lifts your mood without negative side effects. Mood lifters include ecstasinergics. Examples of ecstasinergics are IAP, and the MDxx series.

AceticBenzylPiperazine – AceticBenzylPiperazine lifts mood and increases energy. It also improves cognition. The dose range is 5mg to 40mg. It’s classified as a nootropic.

Sunifiram – Sunifiram is a drug that lifts mood and may improve memory. The dose range is 5mg to 25mg. It’s classified as a nootropic.

IAP(IndanylAminoPropane). IndanylAminoPropane is a mild psychedelic that mildly activates 5HT2a and also releases serotonin, norephinephrine, and dopamine in equal amounts. It promotes a peaceful mindset, reduces anger and irritability, enhances the sound of music and brightens colors. It lifts mood mildly to moderately. The dose range is 15mg to 50mg. The effects last 3 to 12 hours.

Kanna plant – Kanna is a plant with mood elevating and memory enhancing properties. It’s active component, mesembrine, is an selective serotonin reuptake inhibitor. In addition, kanna activates PDE4 inhibitor. This plant was used since ancient times by hunter gatherers.

WIN 55,212-2 : WIN 55,212-2 is a mild mood elevating drug with properties that reduce Altzeimer’s disease.

MDEA (3,4-Methylenedioxyethylamphetamine) : 3,4-Methylenedioxyethylamphetamine is an ecstasinergic compound of the MDxx chemical family. It has a higher affinity for the 5HT2a thanIndanylAminoPropane (though it’s still semi-moderate affinity). It induces the release of serotonin, norephinephrine, and dopamine in equal amounts. It promotes a peaceful mindset, reduces anger and irritability, enhances the sound of music and brightens colors. It also increases energy. Since it causes so much release of brain chemicals, MDEA must not be used more than once a month.  MDEA causes overheating, so it MUST be stacked with 10mg or more of baclofen to avoid overheating. It’s great for dancing for hours at a party with glowing lights. It would also be advisable to take 5-HTP and L-Tyrosine to help the brain replenish serotonin, norepinephrine and dopamine faster. Since MDEA causes teeth grinding and possible dehydration, wearing custom made mouth guards and bringing a bottle or two of water and powerade is also recommended. The dose range of MDEA is 100mg to 160mg. This is classified as a quasinootropic.

2m2bOH, 2-methyl-2-butyl alcohol, or 2-methyl-2-butanol : 2m2bOH is an anxiolytic which elevates mood and enhances sociability. The dose range of 2-methyl-2-butanol is 2ml to 6ml. 2m2bOH is classified as a quasinootropic. Chemical dehydration of 2m2bOH (2-methyl-2-butanol) yields 2m2b (2-methyl-2-butene) and 2m1b (2-methy-1-butene).

Concentration enhancers.

Concentration enhancers are drugs that enhance concentration and focus.  Concentration is important during class, while driving, and doing other tedious tasks. They are a type of nootropic

Here is a list of concentration enhancers. They are:

Nefiracetam – Nefiracetam enhances concentration. It may enhance memory. Dose range is between 250mg and 1,900mg. It’s classified as a mild nootropic.

Oxiracetam – Oxiracetam is a drug that enhances concentration and focus. The dose range is 800mg to2,400mg. It’s classified as a mild nootropic.

Phenylpiracetam – Phenylpiracetam is a drug that somewhat increases energy, increases concentration, and promotes learning. The dose range of phenylpiracetam is 100mg to 250mg. It’s classified as a moderate nootropic.

Phenylpiracetam Hydrazide – Phenylpiracetam hydrazide is another nootropic that is a concentration enhancer and energy enhancer. It increases energy, concentration, and promotes learning. Phenylpiracetam hydrazide reaches full nootropic status. Phenylpiracetam hydrazide’s dose range is 50mg to 150mg and it’s used 1 to 5 times a week. This new nootropic is pretty potent.

 

CILTEP – CILTEP is a natural nootropic stack with artichoke and forkskolin. CILTEP is classified as a nootropic.

Racetams – Racetams are concentration enhanncers that are usually mild to moderate nootropics. Quite rarely do they ever reach full nootropic status. Racetams do, however, increase the effect of psychedelics and low dose psychedelics. So there might be a future where people stack racetams with low dose psychedelics to recreate NZT from limitless-

Memory and problem solving skills enhancers.

Memory and problem solving skills enhancers are the most interesting class of nootropics. They are the only nootropics to actually increase IQ. They encourage higher level thinking and even critical thinking. That wierd hippie that smells like licorice extract with the tie die shirt and the weird lava lamp eating those crazy mushrooms had it right all along (sort of. I’ll explain later). Psychedelics do increase cognition (at psychedelic doses, they increase creativity and insight, while at lower doses, they increases memory and problem solving skills. 2C-x are the perfect example). Psilocybe cubensis mushrooms increase neuron growth at low doses. 2C-I at low doses increases energy. 2C-D at low doses increases memory and problem solving skills. 2C-C at low doses is an anti-anxiety. Taking low doses of psychedelics (“microdosing”, or “mini-dosing”) is one of the least studied areas of psychopharmacology. Here are the hypranootropic we’ve all been waiting for. Maybe it would be better stacked with each other?

Side note: One day, in a reasonable universe, the 2C-x series would be greatly expanded with new additions that would lead to the molecule that would produce intellectual singularity. Otherwise, it would take 60+ years of taking low dose 2C-x series to achieve a four digit IQ. Ooount severe Limitless NZT in real life. 2C-∞ , or 2C-Infinity! Reaching intellectual singularity.

2C-D (2,5-dimethoxy-4-methylphenethylamine) : 2C-D is a psychedelic that exibits nootropic properties at lower doses.  It has been shown to provide exponential growth in intelligence (though at first, it’s not the most noticeable).  It increases intellect, problem solving skills, memory, and cognition. It leaves you with a thirst for knowledge and can even induce the ability to think critically. 2C-D increases the effects of other drugs(especially psychedelics) The dose range is 1mg to 10mg. 2C-D is classified as a hypranootropic.

2C-2P (2C-IP) – This is a new molecule of the 2C-x series. It’s a psychedelic that at lower(sub-psychedelic) doses enhances memory and problem solving skills. The nootropic dose range is 5mg to 15mg.

2C-I and 2C-D stack – The “NZT stack” is a revolutionary stack. Though a lot of dose remodification may be necessary. The dose range of the stack is lower than the dose range of the individual drugs because stacking enhances the effects of all the drugs in the stack. The dose range is 2C-I (1mg to 4mg) added to 2C-D (1mg to 7mg). DMAA(Dimethylamylamine) may also be added at a dose range of 15mg to 35mg, but that would be pushing it a little.

The nerd nectar stack – The nerd nectar stack is usually 20mg to 50mg of dimethylamylamine(or 20mg to 60mg of prolintane), a choline pill (about 500mg), about 80g to 160mg of phenylpiracetam, and 200mg to 600mg of sulbutiamine(in a tablet made by a pill machine or bought tablets). The DMAA(or prolintane) can be either pressed in a tablet or mixed with juice or fruit punch. The phenylpiracetam can be either pressed in a tablet or mixed with juice or fruit punch or maybe Hi C juice. You can mix DMAA(or Prolintane) and Phenylpiracetam in an energy drink or caffeinated sodas if you want.

Daffodils – Daffodils are nootropics that enhance learning. Daffodils contain galantamine. Eat up!

Hyacinth – Hyacinth is a plant with nootropic properties. Hyacinths attract bees. Hyacinths contain small amounts of 1,4-dimethoxybenzene. Eat one or two flower petals, but don’t eat too much, or you’ll be sorry.

Moving on

Supplements.

Supplements are vitamins and minerals that help you. They help replenish your body and the receptor levels in your brain.

Here’s a list of important supplements:

Sulbutiamine – Sulbutiamine helps replenish vitamin b1(thiamine) levels in your brain. Unlike regular thiamine, sulbutiamine can cross the blood brain barrier more easily. Low vitamin B1 levels are common among alcoholics as alcohol(ethanol, ethyl alcohol) destroys vitamin b1. In addition, acetaldehyde(ethanol’s toxic metabolite)does some damage before being converted to it’s non toxic metabolite, acetic acid. Even normal people may have a mild thiamine defecit. The dose range is 150mg to 600mg of Sulbutiamine a day. This is considered a nootropic-

Vitamin B12 – Vitamin B12 is another important vitamin. It is essential for your mind and muscles. Vitamin B12 tend to be low in people who use nitrous oxide(laughing gas) recreationally.  Nitrous oxide destroys some of the Vitamin B12 in the body. Taking Vitamin B12 before breathing nitrous oxide solves this issue. This is considered a nootropic.

L-Tyrosine : L-tyrosine helps replenish dopamine and norepinephrine in the brain. This is considered a nootropic.

5-HTP : 5-HTP helps replenish serotonin levels in the brain. This is classified as a nootropic.

L-Tryptofan, or Vitamin-T : L-Tryptofan is vital! it replenished melotonin and serotonin in your brain and is a presursor to them. Governments are  trying to ban this helpful supplement.

Quercetin – Quercetin is a supplement that widens blood vessels. It can counteract the vacoconsctricting(blood vessel narriwing) properties of some drugs by causing vasodialation(blood vessel widening). It’s also useful when stacked with other nootropic drugs. The dose range for quercetin is is 50mg to 375mg a day. Quercetin is considered a mild nootropic.

Pyritinol – Pyritinol is a form of Vitamin B6 that can cross the blood brain barrier more easily. It’s the disulfide form of Vitamin B6, so it contains sulfer as well. The dose range of pyritinol is 80mg to 800mg. Pyritinol is classified as a mild to moderate nootropic.

Choline – Choline is a supplement that has nootropic properties. The daily dose is 25mg to 2,500mg a day. This is classified as a nootropic.

Anti-oxidants.

Anti-oxidants are foods, supplements, and drugs that fight off free radicals and oxidative stress.

Sesamol – Sesamol is an anti-oxidant found in small amounts in sesame seeds. It’s a very effective anti-oxidant. It has even been shown to protect you against some forms of mild to moderate radiation. The dose range for sesamol is estimated to be 1mg to 500mg. Sesamol is classified as a nootropic.

Resvaratrol – Resveratrol is an an anti-oxidant that has anti-aging properties. Resveratrol may also boost energy. The dose of resveratrol is 25mg to 500mg. A handful of grapes or some unsweetened grape juice would suffice. Resveratrol is classified as a moderate nootropic.

Cherries and cherry juice – Cherries are a fruit that speed up the body’s recovery, and has anthocyanins that have anti-inflammatory properties. The dose is an 8 oz glass of cherry juice or a handful or two of cherries. Cherries and cherry juice is classified as a moderate nootropic.

Blackberries – Blackberries are a fruit with anti-oxidant properties. The dose range is a handful of blackberries to half a pound of blackberries. Blackberries are classified as a moderate nootropic.

Neuron growers (neurogenesis inducers)

Neurogenesis inducers are drugs that increases the growth of neurons. Increased neurons may lead to increased intelligence and grew matter. Excercise induces neurogenesis as well.

A list of neurogenesis inducers. They are:

NSI-189 : NSI-189 is a nootropic and neurogenic research chemical.

NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation. NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20%. It has also been shown to be effective on humans. NSI-189 is classified as a nootropic.

Exercise – Exercise helps the body and brain work better. In addition to keeping you fit, it also induces neurogenesis. 30 minutes of exercise or more is recommended per day.

Psilocybe Cubensis Mushrooms – Psilocybe cubensis mushrooms(or “shrooms”) are a psychedelic mushroom. Although psychedelic doses produce hallucinations, lower doses have been shown to produce neurogenesis. The nootropic dose is usually around a quarter to about half the dose that produces hallucinations. Shrooms is classified as a nootropic.

9-Me-BC. 9-Me-BC is a hypranootropic that produces neurogenesis(growth of new neurons), increases the number of dopamine neurons, increases dopamine content in the brain(especially the hippocampus), upregulates the sonic hedgehog gene(highly beneficial for the brain), increases dendrites and dendritic spines(increasing neuron density and neuron connections), can help reduce stimulant tolerance, increases motivation, raises intelligence levels, and can help raise the theoretical happiness ceiling towards superhappiness and beyond. The dose is 10mg to 80mg.

Lanicemine – Lanicemine is a drug with anti-depressant and neuroprotective qualities. Lanicemine is classified as a hypranootropic.

Other  (ambiguous, undefined nootropic properties).

Other nootropics have ambiguous nootropic properties.

Here’s a list. They are:

2-Aminoindane

2-Aminotetralin

2C-Bu

2C-G-N(eugeroic)

2C-I(Sub-hallucinogenic dose, SHD)

2C-Ph

Adrafinil(eugeroic)

Agomelatin(improves sleep)

Amobarbital(may help create selective false memories and experiences you choose with great and vivid memory of the events. May also cause temporary hypermnesia.)

Propranolol(beta blocker that reduces fear)

Robalzotan

S-17092

S-18986

Selegiline – Selegiline is an MAO-I which helps prevent the breakdown of dopamine, epinephrine, norepinephrine, and possibly serotonin. That means that the catecholamine neurotransmitters stay in the brain longer. Selegiline also has neuroprotective qualities. The dose is 5mg to 40mg+.

Memantine – Memantine can help protect the brain. Memantine also can help reduce the tolerance from stimulants and opioids. Memantine is a partial antagonist of the NMDA receptors.

Curcumin and Piperine combo – Curcumin can improve mood, reduce inflammation, help reduce the risk of cancer, help prevent stress induced mood dysregulation, and can help prevent and reverse drug tolerance. Curcumin(200mg to 1,500mg+) is combined with piperine(5mg to 20mg) to make the curcumin more bioavailable and increase absorbtion by around 2000%. The mechanism for lifting mood and for helping prevent tolerance is by acting as a CREB antagonist. By antagonizing CREB, turmeric helps to prevent epigenetic changes from stress and substances, potentially blocking the dysphoric dynorphin from forming and preventing extreme anxiety and depression. More studies are needed.

Pitolisant

NRX-1074

Clean Healthy colon(parasites are known to reduce energy and fog cognition. Clearing them away can improve energy and cognition).

Dexanabinol

Flodafinil

Fluorenol

GABA

GLYX-13

NESS-0327

Nitrous Oxide(When Vitamin B12 is taken an hour before)

Phenibut

PWZ-029

PF-4455242 – Helps improve mood and blocks the effects of evil dynorphin by being a kappa antagonist, leading to reduced anxiety and improved mood levels.

Tetrahydropalmatine

Stiminsomfinil – Stiminsomfinil is a combination eugeroic and stimulant. The dose range of stiminsomfinil is 80mg to 300mg. It’s classified as a novel nootropic.

SR-59,230-A

Win-41,528-2 (Fezolamine)

WIN 55,212-2

Xenon

E-55888

Arecoline(stimulant)

Atagabalin

Benzofuranylpropylaminopentane (nootropic)

Benzothiophenylcyclohexylpiperidine (BTCP. Pseudonootropic)

Boron

Cannabidiol(CBD. Antioxidant with cholinergic properties)

Diclazepam (anxiolytic. Quasinootropic)

Diphenidine

Donezepil

Ensaculin

MT-45 or IC-6 : Pain killer

Methiopropamine

a-PHP

Ibogaine

TriMethylGlycine(stimulant)

PP-028, Piperonyl Piperidine, or Piperonylic Piperidine : PP-028 is a drug based on CX-546. It’s prepared by the consendation of piperonylic acid and piperidine. PP-028 is classified as a hypranootropic.

Moclobemide: Moclobemide is an MAO-I nootropic.

Bromantane: Bromantane is a nootropic that enhances your brain’s ability to create serotonin and dopamine epigenetically. Bromantane makes your brain receptors more efficient and upregulates them. Bromantane is also good for exercise. Bromantane can lift mood. Bromantane may even help reverse the tolerance to stimulants.

Seroquel

Benperidol.

Vortioxetine

Yohimbine

Zylofuramine